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filingDate 1982-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1983-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_124486246b8e66747083bb3fca0c61a4
publicationDate 1983-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4388412-A
titleOfInvention Immunoassay of phospholipid, such as phosphatidylcholine, in fluids such as amniotic
abstract An immunologic assay for determining the presence of one or more phospholipids in a biological fluid. The method includes adding an ethanolic solution of diacylphosphatidylcholine or alkyltrimethylammonium halide and cholesterol to the biological fluid forming a macromolecular aggregate complex solution. To this solution is added antibody molecules to the phospholipids in an aqueous buffered medium causing an agglutination reaction. The product of the reaction is then examined to determine the presence of the phospholipids. n The method is particularly useful in determining the presence of phosphatidylglycerol in a sample of amniotic fluid. Thus, the assay may be used in evaluating fetal lung maturity.
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