http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4388243-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1374dd16777534b65ad4422333245af8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 |
| filingDate | 1982-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1983-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c25440c1c5dd4b2cc880a922187f5f52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4d21366bb786f5d87e4d17295c2a5dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6576e2785f80ae0855620bb32a298632 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d25df5da84cb98394ad0bc2cc741b3f9 |
| publicationDate | 1983-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4388243-A |
| titleOfInvention | Process for the preparation of active-type vitamin D3 compounds |
| abstract | The present invention relates to a novel process for the preparation of active-type vitamin D 3 compounds and their intermediates. In accordance with the present invention, a large amount of an active-type vitamin D 3 compounds, for example 1α-hydroxycholecalciferol, 1α,25-dihydroxycholecalciferol and the like, is efficiently prepared with high industrial advantages by a novel processes, which comprises (i) reacting hydroxycholesta-5-enes having the hydroxyl groups protected with lower alkoxycarbonyl group as a starting material with allylic brominating agent and dehydrobrominating agent to prepare the corresponding hydroxycholesta-5,7-dienes, (ii) exposing the hydroxycholesta-5,7-dienes to ultraviolet irradiation or to a combination of the irradiation with thermal isomerization to obtain a mixture of the unreacted hydroxycholesta-5,7-dienes and previtamin D 3 compounds or a mixture of the unreacted hydroxycholesta-5,7-dienes and the protected active-type vitamin D 3 compounds, (iii) separating the mixture into the unreacted hydroxycholesta-5,7-dienes and previtamin D 3 compounds or the protected active-type vitamin D 3 compounds, (iv) recycling the unreacted hydroxycholesta-5,7-dienes as reuse and (v) thermally isomerizing the remaining compounds and/or splitting off the protective groups. The process for the preparation of active-type vitamin D 3 compounds, in the present invention, is of very high industrial value, capable of carrying out by simple operation and adaptable to large scale commercial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009137536-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004043971-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7094775-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010087404-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6242434-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006211661-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4711881-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6441207-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5972917-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006003021-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5789607-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006003950-A1 |
| priorityDate | 1979-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 296.