| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d709e3167fa2f99a1803c9cfeb0aca63 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D457-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D457-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 |
| filingDate |
1980-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1983-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e144fdccc9be3e161c7489e226d3cd9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_275212500fc4efe80d76db84605892db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4a51eb3bc117d27694290a0ccde26b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd0ff74c97566eb79030ee6c38baeca0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf4b9db3a7419cbe7d5c324aea037d02 |
| publicationDate |
1983-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4382940-A |
| titleOfInvention |
Ercoline derivatives and therapeutic compositions having CNS affecting activity |
| abstract |
Compounds are disclosed of formula (I) <IMAGE> (I) wherein R1 represents a hydrogen atom or a methyl group; R2 represents a hydrogen atom or a methoxy group; X represents an oxygen or sulphur atom or an NH or NCH3 group; R3 represents a hydrogen atom, a trifluoromethyl or phenyl group or a hydrocarbon group having from 1 to 4 carbon atoms; R4 represents a hydrogen atom, a methyl or acetyl group or a hydrocarbon having from 1 to 4 carbon atoms, or R3 and R4 together represent a 3- or 4-membered carbon atom chain; Y represents an electron-withdrawing group such as a cyano, nitro, alkylsulphonyl or alkylsulprinyl group or a group of the formula COR5 wherein R5 represents an alkyl group having from 1 to 4 carbon atoms or a phenyl, alkoxy, amino or N-substituted amino group or R5 and R3 together represent a 2- or 3-membered carbon atom chain; R6 represents a hydrocarbon group having from 1 to 4 carbon atoms or a benzyl or phenethyl group; and R7 represents a hydrogen or halogen atom or a methyl or formyl group or a group of the formula SR8 wherein R8 represents a hydrocarbon group having from 1 to 4 carbon atoms or a phenyl group; and the pharmaceutically acceptable addition salts with organic or inorganic acids thereof. A process for producing these compounds is also disclosed. These compounds are useful antidepressant, anxiolytic and neuroleptic agents. They also display from moderate to good antiprolactinic and antihypertensive activity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-3413660-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4731367-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4847262-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4720498-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4683313-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4843073-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4801712-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5430031-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4657914-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4826851-A |
| priorityDate |
1979-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |