| abstract |
A compound of the formula (I) and pharmaceutically acceptable salts thereof: <IMAGE> (I) wherein: Ar is phenyl, optionally substituted by one or more C1-4 alkyl, C1-4 alkoxy, halogen, cyano, nitro, hydroxy, CONH2, CO2W wherein W is C1-6 alkyl or C1-4 alkylphenyl which phenyl may be substituted by one or more C1-4 alkyl, C1-4 alkoxy or halogen, NR1R2 wherein R1 and R2 are selected from hydrogen or C1-6 alkyl, NHCO C1-6 alkyl or C1-6 alkylcarbonyloxy; phenyl disubstituted on adjacent carbon atoms by methylenedioxy; furyl or thienyl; the dotted lines represent an optionally present double bond; and X is CO or CR1OH wherein R1 is hydrogen or C1-4 alkyl, having useful pharmacological activity, processes for their preparation and their use. |