http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4377691-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34213bc96042a6ad7d4f2708e0a27168 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-14 |
| filingDate | 1980-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1983-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_687841851b7dd288b11204a282f190b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98fa205593bb888f92a498f1f9d6345c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ad0fdd066f4c1a8c410ccc7c1a12651 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e98b5a44764f52e1c79ff949d4d618f6 |
| publicationDate | 1983-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4377691-A |
| titleOfInvention | Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid-addition salts thereof |
| abstract | A process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol (i.e. ifenprodil) and acid-addition salts thereof, characterized by brominating 4'-hydroxypropiophenone in a single or mixed solvent selected from the group consisting of methanol, ethanol and a saturated aliphatic ether, removing hydrogen bromide formed in the course of the bromination, adding 4-benzylpyridine to the reaction mixture, heating the reaction mixture under reflux in a single or mixed solvent selected from the group consisting of methanol and ethanol, and then subjecting the resultant reaction mixture to catalytic reduction to form 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol hydrobromide in the reaction mixture. The end product (i.e. ifenprodil) can be obtained according to this process in a high yield of about 80% within 14 hours from the starting material in a single reaction container throughout the process, without introducing a protective benzyl group into the starting material prior to the bromination. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5663349-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101100453-B |
| priorityDate | 1979-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 126.