| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dba2770e2208820159bc997e46b65a7f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-837
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S930-18 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-26 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-26 |
| filingDate |
1980-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1983-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5912320614feaff5d588c7107e6a2c13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54975e25fb465cb3224aaa6152ef5503
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d54100b4b325e855d7255869c65b0be0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b57445a10d352e473ba14aec6797681b |
| publicationDate |
1983-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4374828-A |
| titleOfInvention |
Biologically active thymones from the thymus |
| abstract |
A class of three substances has been isolated in highly purified form and in substantially pure form by utilizing thymus tissue as a source material. These three substances are designated thymone A, thymone B and thymone C. Thymones A and B are new peptides which yield approximately 13 and 14 individual amino acid moieties, respectively, on acid hydrolysis. Thymones A and B are chemically characterized by electrophoretic and chromatographic values which are appropriate for substances which are substantially pure. Thymone C was highly purified and its biological activity was reproducibly detected and measured. Thymones A, B and C stimulate the proliferation of lymphocytes. Thymone A stimulates the formation of cyclic adenosine monophosphate. Thymone B stimulates the formation of cyclic guanosine monophosphate. The biological activities of these thymones to stimulate the proliferation of lymphocytes and the formations of cyclic nucleotides are basic hormonal functions for the therapeutic enhancement of the immune system in patients who have immune deficiencies from diverse causes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5807830-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5070076-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002052321-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-3633651-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5728680-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4904643-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6368788-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6100380-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4814434-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4548813-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6066622-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7723491-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6346514-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5770576-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8401090-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6777195-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4621135-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5811399-A |
| priorityDate |
1980-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |