| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b919a09598a02c07e8429b1441b76e1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C201-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-333
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C53-132
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-56 |
| filingDate |
1981-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1983-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5569b533925b68fcf5c0086a82b5d9be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ede78182b3377d3775195a94c77e1573 |
| publicationDate |
1983-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4370278-A |
| titleOfInvention |
Nucleophilic substitution process |
| abstract |
2-(Fluoronitrobenzene)alkyl cyanides are prepared by reacting a fluoronitrobenzene with an alpha-substituted alkyl cyanide in a substantially anhydrous aprotic solvent and in the presence of a base so that the alkyl cyanide reactant undergoes a nucleophilic substitution reaction on an unsubstituted carbon atom of the fluoronitrobenzene during which the alpha-substituent of the alkyl cyanide reactant functions as a leaving group. Use of 2-fluoronitrobenzene and an alpha-substituted propionitrile (e.g., 2-chloropropionitrile) produces a novel compound, 2-(3-fluoro-4-nitrobenzene)propionitrile. Reduction of the nitro substituent produces another novel compound, 2-(4-amino-3-fluorobenzene)proprionitrile. This can readily be converted to 2-(3-fluoro-4-biphenylyl)propionitrile by means of a Gomberg-Bachmann reaction with an aromatic hydrocarbon or substituted aromatic hydrocarbon which in turn can be converted on hydrolysis into the corresponding 2-(2-fluoro-4-biphenylyl)propionic acid. Use of benzene in the Gomberg-Bachmann reaction thus enables production of flurbiprofen, a well-known pharmaceutical. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4540795-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4721790-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4541961-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4503000-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4482502-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4502999-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4479904-A |
| priorityDate |
1981-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |