| abstract |
Certain 2-(1-imidazolylmethyl)pyridine compounds, having a further substituent O-Y-Z at the 3- or 5-position of the pyridine ring. Y is -(CH2)n-, -CH2C6H4-, or -CH2(Het)-, where n is an integer from 1 to 4 and Het is a heterocyclic group; Z is a carboxy (COOH) or carboxycarbonyl (COCOOH) group, or an ester or amide derivative thereof. The compounds of the invention selectively inhibit the thromboxane synthetase enzyme, without significantly inhibiting the action of the prostacyclic or cyclo-oxygenase enzymes in animals, including man. The compounds are useful, therefore, in the treatment of thrombosis, ischaemic heart disease, stroke, transient ischaemic attack, migraine and the vascular complications of diabetes. |