| abstract |
Easily split enzyme substrates for the quantification of proteases having the general formula n n R.sub.1 --p-Glu--A.sub.1 --A.sub.2 --NH--R.sub.2, n n where n R 1 =H or a protective group, preferably t-butyloxycarbonyl, benzyloxycarbonyl; n A 1 =Gly, Ala, Val, Leu, Ile, Ser, Thr, Pro, Pip, Phe or Tyr; n A 2 =Arg or Lys; n R 2 =an aromatic, possibly substituted, hydrocarbon group, wherein --NH--R 2 is a physico-chemically determinable group, preferably a chromogenic or fluorogenic group which is split by a present enzyme and then forms a cleavage product of the formula H 2 N--R 2 the amount of which can be quantified. n Processes for the production of said substrates. Method in the laboratory diagnostics of proteases using said substrates. |