http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4330465-A
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-6755 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-655 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
filingDate | 1978-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 1982-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f8071ee5c52d842338b603c3ad6734e |
publicationDate | 1982-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-4330465-A |
titleOfInvention | Novel β-endorphin analogs |
abstract | The solid-phase syntheses of [Ala2]-, [D-Leu2]-, [D-Lys2], [Leu5]- and [D-Ala2, D-Leu5] beta -endorphins are described. The synthetic peptides were purified by chromatography on carboxymethylcellulose and partition chromatography on Sephadex G-50. They were characterized by partition chromatography on agarose, thin-layer chromatography, paper electrophoresis, and amino acid analyses of acid and enzymic hydrolysates. Bioassay of the synthetic analogs for analgesic activity by the tail-flick-method showed the D-Leu2 analog to be 48% as potent as beta h-endorphin while the Ala2, D-Lys2, Leu5, and [D-Ala2, D-Leu5] analogs were 8 to 17% as active. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4855112-A |
priorityDate | 1978-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 544.