http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4328340-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D253-075 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D253-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D253-06 |
| filingDate | 1981-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1982-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b56da418c002601ec142d2302858916a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6d4e480c80516f94e264c1934178360 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_860b2e0250f96bdc759ec85b74a9ba5a |
| publicationDate | 1982-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4328340-A |
| titleOfInvention | Preparation of 4-amino-6-tert.-butyl-3-alkylthio-1,2,4-triazin-5-(4H)-ones |
| abstract | In the preparation of 4-amino-6-tert.-butyl-3-methylthio-1,2,4-triazin-5-(4H)-one of the formula ##STR1## wherein pivaloyl cyanide of the formula n n (CH.sub.3).sub.3 C--CO--CN n n is reacted to form an intermediate, the intermediate is condensed with thiocarbohydrazide of the formula n n NH.sub.2 --NH--CS--NH--NH.sub.2 n n to form 4-amino-6-tert.-butyl-3-mercapto-1,2,4-triazin-5-(4H)-one of the formula ##STR2## and the 4-amino-6-tert.-butyl-3-mercapto-1,2,4-triazin-5-(4H)-one is alkylated to replace the H atom on the sulphur by --C 1-4 --alkyl, the improvement which comprises reacting the pivaloyl cyanide with a carboxylic acid anhydride of the formula n n R--CO--O--CO--R n n in which R is an optionally substituted aliphatic radical with up to 8 carbon atoms or an optionally substituted phenyl radical, in the presence of a strong acid at a temperature between about -50° and +150° C., and then directly reacting the reaction mixture thus obtained with the thiocarbahydrazide. Advantageously R is CH 3 , the strong acid is concentrated sulphuric acid, the pivaloyl cyanide is effected at a temperature between about 0° and 100° C., the condensation with thiocarbohydrazide is effected, in the presence of a mineral acid, in an aqueous or aqueous-alcoholic medium, and the alkylation is effected using methyl iodide or methyl bromide in the presence of sodium hydroxide at about 0° to 50° C. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5292949-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0144669-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4544744-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4546178-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5440038-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4436905-A |
| priorityDate | 1980-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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