abstract |
Compounds of the formula <IMAGE> wherein R4 is C1-C6 alkyl and R1 is an N-alkanoyl amino acyl group of the formula <IMAGE> wherein: W is a divalent aminoacycl radical of the formula <IMAGE> (a) wherein A is C1-C10 alkylene or C5-C6 cycloalkylene; <IMAGE> (b) wherein R3 is hydroxymethyl, hydroxyethyl, mercaptomethyl, mercaptoethyl, methylthioethyl, 2-thienyl, 3-indolemethyl, phenyl, benzyl, or substituted phenyl or substituted benzyl in which the benzene ring thereof is substituted with chloro, bromo, iodo, nitro, C1-C3 alkyl, hydroxy, C1-C3 alkylthio, carbamyl, or C1-C3 alkylcarbamyl; <IMAGE> (c) wherein X is hydrogen, chloro, bromo, iodo, nitro, C1-C3 alkyl, hydroxy, C1-C3 alkoxy, mercapto, C1-C3 alkylthio, carbamyl, or C1-C3 alkylcarbamyl; <IMAGE> (d) wherein X1 is chloro, bromo, or iodo; <IMAGE> (e) <IMAGE>,4 NH+RE (f) wherein B is a divalent radical of the formula:-(CH2)n-, wherein n is an integer from 1 to 3; -CH=CH-; <IMAGE> and R2 is C1-C17 alky or C2-C17 alkenyl; have antifungal activity. |