| abstract |
Compounds of the formula <IMAGE> wherein R1 is an N-alkanoyl amino acyl group of the formula <IMAGE> wherein: W is a divalent aminoacyl radical of the formula: <IMAGE> wherein A is C1-C10 alkylene or C5-C6 cycloalkylene; <IMAGE> wherein R3 is hydroxymethyl, hydroxyethyl, mercaptomethyl, mercaptoethyl, methylthioethyl, 2-thienyl, 3-indole-methyl, phenyl, benzyl, or substituted phenyl or substituted benzyl in which the benzene ring thereof is substituted with chloro, bromo, iodo, nitro, C1-C3 alkyl, hydroxy, C1-C3 alkylthio, carbamyl, or C1-C3 alkylcarbamyl; <IMAGE> wherein X is hydrogen, chloro, bromo, iodo, nitro, C1-C3 alkyl, hydroxy, C1-C3 alkoxy, mercapto, C1-C3 alkylthio, carbamyl, or C1-C3 alkylcarbamyl; <IMAGE> wherein X1 is chloro, bromo, or iodo; <IMAGE> +TR <IMAGE>0 ..NH+RE wherein B is a divalent radical of the formula: -(CH2)n-, wherein n is an integer from 1 to 3; -CH=CH-; -CH=CH-CH2-; <IMAGE> and R2 is C1-C17 alkyl or C2-C17 alkenyl; have antifungal activity. |