| abstract |
Prostaglandin analogs are disclosed that have the α-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C 1 to C 4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C 1 to C 4 alkyl, C 1 to C 4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators. |