http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4288443-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-341 |
| filingDate | 1980-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1981-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ae061ab3f7cd8ad11023fb614b4fa07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09d695d998d309cfb4b64324c05b3564 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_964aa1841dbe223cd0406120c1725857 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81fe9984a7bc6171b3f87be46ea8e773 |
| publicationDate | 1981-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4288443-A |
| titleOfInvention | Substituted furan compounds and pharmaceutical compositions containing them |
| abstract | The invention relates to compounds of the general formula <IMAGE> (I) and physiologically acceptable salts and N-oxides, hydrates and bioprecursors thereof, in which R1 and R2 which may be the same or different each represent hydrogen, C1-8 alkyl, C4-8 cycloalkyl, C3-6 alkenyl, aralkyl with 1 to 4 carbon atoms in the alkyl residue or C1-8 alkyl interrupted by an oxygen atom or a group <IMAGE> in which R5 represents hydrogen or C1-8 alkyl, or R1 and R2 may together with the nitrogen atom to which they are attached, form a saturated monocyclic 5 to 7 membered heterocyclic ring which may additionally contain the heterofunction O or <IMAGE> R3 represents straight or branched chain C1-8 alkyl, alkoxyalkyl with 1 to 8 carbon atoms in each alkyl residue, C1-8 hydroxyalkyl, C1-8 alkoxycarbonyl, alkyl thioalkyl with 1 to 8 carbon atoms in each alkyl residue, halogen or aryl; R4 represents hydrogen, C1-8 alkyl, C3-6 alkenyl or alkoxyalkyl with 1 to 8 carbon atoms in each alkyl residue; X represents -O- or -S-; Y represents =S, =O, =NR6 or =CHNO2 where R6 represents hydrogen, nitro, cyano, C1-8 alkyl, aryl, C1-8 alkylsulphonyl or arylsulphonyl; m represents an integer from 2 to 4 inclusive; and n represents an integer which is 1 or 2, or additionally when X is -S- n may also be zero. The invention also relates to processes for the production of such compounds, pharmaceutical compositions containing them and certain novel intermediates used in their production, i.e. amines of the formula <IMAGE> (III) and alcohols of the formula <IMAGE> (VIII) The compounds of formula (I) show pharmacological activity as selective histamine H2-antagonists. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022034121-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4980371-A |
| priorityDate | 1977-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 481.