| abstract |
Compounds useful for pharmacological and medicinal purposes having the formulae <IMAGE> +TR <IMAGE> wherein R is H, C1-C5 alkanoyl; R1 is H, benzyl, C114 C5 alkanoyl, P(O)(OH)2, -CO(CH2)2COOH or a basic acyl group; each of R2 and R4 is H, C1-C6 alkyl, phenyl, pyridyl or (CH2)yC6H5; y is 1-4; R3 is H or CH3; Z is C1-C13 alkylene or -(alk1)m-O-(alk2)n-; each of (alk1) and (alk2) is C1-C13 alkylene with the proviso that the summation of carbon atoms in (alk1) plus (alk2) is not greater than 13; each of m and n is 0 or 1; and W is H, pyridyl, phenyl, fluorophenyl or chlorophenyl; intermediates therefor and methods for their preparation and use. |