| abstract |
Prostanoic acid derivatives of the formula ##STR1## wherein R 1 is an acid, ester, amide or hydroxyalkylene group; R 2 and R 3 are H or alkyl; R 4 and R 5 are both CH 3 or one is Cl and the other is CH 3 ; A is CH 2 CH 2 or --CH═CH; B is CH 2 CH 2 , trans-CH═CH, --C.tbd.C--or ##STR2## W is free or functionally modified hydroxyalkylene or carbonyl; Z is free or functionally modified hydroxymethylene or carbonyl; X Y is either ##STR3## or, when Z is free or functionally modified hydroxymethylene, ##STR4## or, when Z is free or functionally modified carbonyl, --CH═CH--, R 12 being H, CH 3 , CN or free or functionally modified hydroxy; and physiologically acceptable salts thereof when R 1 is an acid group, possess pharmacological activity, including abortion triggering activity. |