| abstract |
Certain pregn-4-ene-3,20-diones or pregn-1,4-diene-3,20-diones 4-substituted with a fluoro or chloro are useful as topical anti-inflammatory steroids. These compounds are substituted at 9 alpha with hydrogen, fluoro, chloro or bromo; at 6 alpha with hydrogen, fluoro or chloro; at the 11 position with a keto, a beta -hydroxy or a beta -chloro (the latter only when there is a 9 alpha -chloro); at 16 alpha , 17 alpha -positions with isopropylidenedioxy or at 16 alpha - (or 16 beta ) with methyl when 17 alpha is hydroxy (or an ester); and at the 21-position with mono-fluoro, chloro, bromo, hydroxy or alkanoyloxy of 2-6 carbons or difluoro, dichloro, dihydroxy or dimethoxy. |