http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4271141-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51b76c0bdacb47d804409c96c9bb94c2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-81 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48 |
| filingDate | 1978-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1981-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eeee7d5d4f91c22801896d3b85c35df7 |
| publicationDate | 1981-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4271141-A |
| titleOfInvention | Radioimmunological method of determining the thyroid function by an in vitro test in blood serum |
| abstract | The present invention provides an improved method for determining the thyroid function by means of an in vitro test using blood serum. Such a method involves an improvement of the procedure whereby (a) a patient's blood serum sample is mixed with a solution containing radioactive thyroxine and with a compound that liberates thyroxine from thyroxine-binding globulin; (b) the test mixture is buffered to achieve proper conditions for carrying out a thyroxine-binding immunoreaction; (c) an antiserum is added to provide antibodies which bind a portion of the thyroxine present by means of such a thyroxine-binding immunoreaction; (d) unbound thyroxine is thereafter separated from the antibody-bound thyroxine; and (e) the relative quantities of bound and unbound thyroxine are then determined by measurement of radioactivity. n In accordance with the present invention, such a procedure is improved by adding to the test mixture, after it has been appropriately buffered, a second additional sample of the patient's blood serum. This second sample of the patient's serum acts as a "correcting" or "normalizing" second binding agent, the addition of which improves the accuracy of thyroid function determination by means of the radioimmunoassay procedure. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4816417-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4478945-A |
| priorityDate | 1977-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.