| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5712b4838bdb16ebbc41121239e165b9 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C57-52 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 |
| filingDate |
1978-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1981-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5092719ca619bc3ca17f85b55d93a443
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62c649fb210bee0305013b29185fe3f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4211364b8e87ee6bea73816a864d0d63 |
| publicationDate |
1981-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4252976-A |
| titleOfInvention |
Process for the preparation of thiophenes |
| abstract |
A process for the preparation of 3-substituted thiophenes which involves cyclization of a novel intermediate, avoids the use of previously employed expensive starting materials. The thiophenes are useful for the preparation of penicillins and cephalosporins. n The process is for the preparation of a thiophene of formula (I): ##STR1## where R 1 represents a carboxylic acid group, or an ester or amide thereof or a nitrile group; R 2 represents a group suitable for use as an α-substituent in the side-chain of a penicillin or cephalosporin; which comprises treating a compound of formula (II): ##STR2## wherein X represents halogen or optionally functionalized hydroxyl, Y represents halogen, hydroxyl, or alkoxy; with a source of nucleophilic sulphur under basic conditions. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5426211-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4362880-A |
| priorityDate |
1977-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |