| abstract |
Compounds of the formula ##STR1## wherein R 1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R 2 is hydrogen, hydroxy, cyano, (lower)alkyl, (lower)alkoxy, halogen or amino; n is 2 or 3; X is NR 3 or CHR 3 ; R 3 is cyano, nitro, SO 2 Ar; or SO 2 (lower)alkyl; R 12 is hydrogen or (CH 2 ) p NR 13 R 14 ; p is an integer of from 1 to 4, inclusive; R 13 and R 14 each are independently hydrogen or (lower)alkyl; and Ar is phenyl or phenyl containing 1 or 2 substituents independently selected from halogen and (lower)alkyl; and nontoxic, pharmaceutically acceptable salts thereof, are potent anti-ulcer agents. |