| abstract |
Compounds having the formula <IMAGE> wherein R1 and R2 are alkyl having one to 4 carbon atoms, allyl or <IMAGE> is pyrrolidino, piperidino, perhydroazepino or morpholino, RX is an inorganic acid, organic acid or an alkyl bromide or iodide, m is 3 or 4, and n is zero or one. The compounds are prepared by (1) reacting benzothienyl-lithium with <IMAGE> followed by hydrolysis, or (2) when the substituent is located at the 2 position of the benzothienyl group, by reacting benzothiophene with <IMAGE> followed by reaction with <IMAGE> The compounds possess bloodplaque aggregation, spasmolytic, analgesic, anti-inflammatory and coronary, cerebral and peripheral vaso-dilatory properties. |