http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4243587-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-085 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 |
| filingDate | 1979-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1981-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d82f8f8ab3072306f5840b9815bea5e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd78085aa66dbe923c974caf78ddd634 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_347382ad6039ff4a10f95efcbe18f478 |
| publicationDate | 1981-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4243587-A |
| titleOfInvention | Process for 3β-aminoazetidin-2-ones |
| abstract | 1-[ alpha -(Carboxy)-4-hydroxybenzyl]-3 beta -aminoazetidin-2-one esters are prepared by converting 2-acyl-3,3-dialkyl-7-oxo- alpha -[4-(benzyloxy)phenyl]-4-thia-2,6-diazabicyclo[3.2.0]-heptane-6-acetic acid esters with mercuric acetate in an aqueous organic solvent mixture, e.g., in aqueous methanol, to 7-oxo-3-phenyl- alpha -[4-(benzyloxy)phenyl]-4-oxa-2,6-diazabicyclo[3.2.0]hept-2-ene-1-acetic acid esters and the latter are reacted with PCl5 and pyridine to provide the monocyclic 1-[ alpha -(carboxy)-4-benzyloxybenzyl]-3 beta -( alpha -chlorobenzylidene-amino)-4-chloroazetidin-2-one esters. Reduction of the dichloro azetidin-2-one with an organo tin hydride and azobisisobutyronitrile affords the deschloro, 1-[ alpha -(carboxy)-4-benzyloxybenzyl]-3 beta -benzylideneaminoazetidin-2-one ester. The latter is hydrolyzed and the 4-benzyloxy group is cleaved via catalytic hydrogenolysis to yield an ester of 1-[ alpha -(carboxy)-4-hydroxybenzyl]-3 beta -aminoazetidin-2-one. The 3 beta -amino ester is useful for the preparation of the antibiotic FR 1923 (nocardicin). |
| priorityDate | 1977-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 417.