http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4234591-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5fb3689bb224dbbee5f993de522c694e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 1979-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1980-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afa199fd1f55a07e6c066dbba7a177ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebc7a31a7339b9d107298e6b5e942666 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_562c17b7de2c2b1d3131250ccf54de68 |
| publicationDate | 1980-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4234591-A |
| titleOfInvention | Analgesic and morphine-antagonistic 9-phenyl-6,7-benzomorphans |
| abstract | The invention is concerned with certain new 6,7-benzomorphan derivatives having pharmacological, in particular analgesic and/or morphine-antagonistic properties, of the formula <IMAGE> wherein R1 is a substituted or unsubstituted phenyl or heteroaryl group; R2 is a hydrogen or halogen atom, or a hydroxy, alkoxy or acyloxy group; R3 is an alkyl or alkenyl group; R4 is a hydrogen atom or a hydroxy, alkoxy or acyloxy group; and R5 is an alkyl group or, when R2 is hydrogen in a trans-position to R3, R5 is a hydrogen atom or an alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, cycloalkenylalkyl, cyanoalkyl, hydroxyalkyl, alkoxyalkyl, or a substituted or unsubstituted phenylalkyl, heteroarylalkyl or heterocycloalkylalkyl group; optical isomers and pharmaceutically acceptable sals thereof. The preferred compound is the alpha -isomer of 2,5-dimethyl- 2'-hydroxy-9-phenyl-6,7-benzomorphan, in particular its (+)-enantiomer. These compounds are prepared by total synthesis and are not derived from opium alkaloids. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9975854-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017073313-A1 |
| priorityDate | 1976-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 310.