http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4229349-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-12 |
| filingDate | 1979-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1980-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb33333c4e1a1c7c07eed109bcf9b710 |
| publicationDate | 1980-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4229349-A |
| titleOfInvention | Production of semi-synthetic β-lactam antibiotics |
| abstract | In the production of a semi-synthetic β-lactam antibiotic by reacting an amino compound of the formula ##STR1## in which X is the remaining members of a ring of a β-lactam antibiotic, and n R is a hydrogen atom or a methoxy group, n with an activated carboxylic acid derivative of the formula ##STR2## in which R 1 is an organic radical, n B is an optionally substituted phenyl, cyclohexadienyl or heterocyclyl radical and n R 2 is a lower alkyl radical, n the improvement which comprises effecting the reaction in an acetone/water mixture which contains acetone and water in a volume ratio of about 0.5:1 to 3:1. Advantageously the reaction is carried out at about -10° to +10° C. in the presence of an organic base employing about 1.1 to 1.2 mols of the amino compound per mol of the activated carboxylic acid derivative. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101550144-B |
| priorityDate | 1978-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.