| abstract |
Herein is disclosed spiroindolone derivatives of the formula ##STR1## in which R 1 is lower alkyl or carboxy(lower)alkyl, R 2 is lower alkyl, R 3 is lower alkyl or phenyl(lower)alkyl, and X is oxygen or CH 2 , or a therapeutically acceptable base addition salt thereof when R 1 is carboxy(lower)alkyl, a process for their preparation, methods of using the derivatives and pharmaceutical compositions of the derivatives. The derivatives are useful for treating hypertension in a mammal. |