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filingDate 1978-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1980-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8601aca0a96a4cec2cf804e53b73411
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publicationDate 1980-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4210420-A
titleOfInvention Detection of fibrin monomer and composition therefor
abstract A quantitative method and composition for precipitating fibrin monomers from plasma in the presence of fibrinogen, with only a small amount, if any, of fibrinogen being precipitated. A buffered precipitating agent is provided having a pH in the range of 6.5±0.5, the buffer being one having a pKa in the range of 6 to 7 and protamine sulfate at a level of 0.025 to 0.2% by weight. Suitable buffers are 2-(N-morpholino)ethanesulfonic acid, sodium phosphate, histidine, maleic acid and imidazole. Analysis of the amount of fibrin present can be made by analyzing for protein using preferably a basic urea solution containing sodium hydroxide and measuring the absorbance at 282 nanometers.
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