| abstract |
Prostaglandin analogues of the general formula: ##STR1## [wherein Y represents ethylene or trans-vinylene, R 1 represents a group --C m H 2m COOR 5 , --C n H 2n OR 6 or ##STR2## (wherein R 5 represents an alkyl group containing from 1 to 4 carbon atoms, R 6 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms, R 7 and R 8 , which may be the same or different, each represents an alkyl group containing from 1 to 4 carbon atoms, m represents an integer of from 1 to 12 and n represents an integer of from 2 to 12), R 2 represents a hydrogen atom or a methyl or ethyl group, R 3 represents a single bond, or an alkylene group containing from 1 to 4 carbon atoms, R 4 represents a hydrogen atom, an alkyl group containing from 1 to 8 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms in the ring, which may be unsubstituted or substituted by at least one alkyl group containing from 1 to 8 carbon atoms, or represents a phenyl or phenoxy group which may be unsubstituted or substituted by at least one chlorine atom, trifluoromethyl group or alkyl group containing from 1 to 3 carbon atoms, the wavy line attached to the carbon atoms in positions 11 and 15 represents α- or β-configuration, or mixtures thereof, and the double bond between C 5 -C 6 is Z] and cyclodextrin clathrates thereof, and, when R 1 represents a group ##STR3## in which n, R 7 and R 8 are as hereinbefore defined, non-toxic acid addition salts thereof, are new compounds and possess characteristic prostaglandin-like properties. |