| abstract |
Aromatic compounds having the following formula are disclosed: <IMAGE> in which, A in the heterocyclic group is selected from the group of O and S; R1, R2, R3 and R4, which may be identical or different, are selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy; R5 is selected from the group consisting of hydrogen, lower alkyl and nitro; n is an integer from 1 to 3 and R6 and R7 together with the nitrogen atom to which they are attached form a 5- to 7-membered N-heterocyclic saturated group which optionally contain a second hetero atom, which may be O or N and pharmaceutically acceptable acid addition salts of the amino group thereof, said compound being in the form of the E isomer of the oximino group, the Z isomer or mixtures thereof. These novel compounds exhibit a coronary vasodilatory activity and may be used in the treatment of cardiopathies. A method of treating such disorders and a composition useful for treating same are also disclosed. |