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publicationDate 1980-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4202665-A
titleOfInvention Detection of hepatitis B surface antigen
abstract The reversed passive hemagglutination test (RPHA) for the detection of hepatitis B surface antigen (HBsAg) is improved by the recognition that the speed of movement towards the periphery of a centrifugal field by immunologically aggregated solid phase support particles, increases proportionally with the amount of antigen present. It is further recognized that this dynamic study can be performed objectively and in an automated fashion by equipment such as the miniature centrifugal fast analyzer. The test performed in this manner and known as "reversed passive hemagglutination by minature centrifugal fast analysis" (RPHA/MCFA) is highly specific and eliminates the need for subsequent confirmational studies. Preliminary studies confirm a sensitivity comparable to other third generation tests.
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