http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4182897-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8452ff10738ff78c36f8e463aebb9a94 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C205-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-18 |
| filingDate | 1978-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1980-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab076feac7a99b26e82dd7a9106be959 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b24138ecfdcaa155253ff5e1009ee3d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8df6fef63e615c838b2b862cf2e406bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_276b7665ac257996053347b12131b4fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36e6555c4d251fe03739f1cdd41a5ff2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74f4926394ddba2a4834ffbd2f2653ae |
| publicationDate | 1980-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4182897-A |
| titleOfInvention | Amino- or guanidino-phenylpropionic acid derivatives |
| abstract | Amino- or guanidino-phenylpropionic ester derivatives represented by the formula: <IMAGE> wherein R is -NH2 or <IMAGE> R1 is hydrogen or a lower alkyl group, and R2 is an unsubstituted or a lower-alkyl-, carboxyalkyl-, lower-alkoxy-, lower-alkoxycarbonyl- or halogen-substituted phenyl group or an unsubstituted or a halogen-substituted naphthyl group, and acid addition salts thereof are novel compounds exhibiting a specific enzyme-inhibitory activity to proteolytic enzymes and, therefore, they are useful as the therapeutic agent of diseases induced by abnormal activation of these enzymes. The above-mentioned compounds can be produced by subjecting a nitrocinnamic acid derivative represented by the formula: <IMAGE> and a phenol derivative or a naphthol derivative represented by the formula: HO-R2 to an esterification in the conventional manner to obtain a nitrocinnamic ester derivative, then reducing the latter compound to obtain an aminophenylpropionic ester derivative and, if desired, reacting it with cyanamide to obtain a guanidino-phenylpropionic ester derivative and, if desired, further converting the reaction product to an acid addition salt. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009080818-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009080818-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010331384-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5218137-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5237089-A |
| priorityDate | 1977-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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