| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a922fc18a4f26bfc3c02d869f4c1d54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ab38efb8969f6bda9caa834c81d3dcab |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-834 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-473
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-22 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-22 |
| filingDate |
1978-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1979-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50e91f8e0bbdf2f57041b84bbf59e3d1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_441ce344a29a188deaed274539b68367 |
| publicationDate |
1979-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4178285-A |
| titleOfInvention |
Separation of active α1 -acid glycoprotein and utilization in the lipoprotein lipase enzyme system |
| abstract |
This invention relates to a method of separating the active alpha 1-acid glycoprotein fraction, a co-factor in the lipoprotein lipase reaction, from urine of nephrotic animals and humans as follows: (a) concentrate the said urine to about 10-20% by volume; (b) precipitate undesired protein at pH 4 with ammonium sulfate; and (c) recover the alpha 1-acid glycoprotein fraction from the supernatant, neutralize with solid NaHCO3, and purify by dialysis versus H2O and lyophilize. This active alpha 1-acid glycoprotein fraction is utilized in effective amounts in nephrotic animals to reverse the defect in triglyceride removal caused by the loss of plasma constituents in urine. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5583201-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0035038-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4482485-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-716333-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0059563-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0035038-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4275056-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4489167-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4801475-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0059563-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5393742-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4663233-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5844097-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9732893-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5364793-A |
| priorityDate |
1978-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |