| abstract |
The present invention provides a process for the preparation of rifampicin, wherein rifamycin S is reacted in an aprotic dipolar solvent with a 1,3,5-trisubstituted hexahydro-1,3,5-triazine at a temperature from 20° to 100° C. followed by reaction with 1-amino-4-methylpiperazine, while keeping the pH in the range of from 5 to 7, whereafter the rifampicin formed is isolated. |