http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4169946-A
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-57 |
filingDate | 1978-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 1979-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_613eed73ccd287298af5520db8cc2146 |
publicationDate | 1979-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-4169946-A |
titleOfInvention | Reactions of thiooxime cephalosporin and penicillin derivatives |
abstract | Compounds of the formula ##STR1## wherein A is ##STR2## R is hydrogen, lower alkyl, benzyl, p-methoxybenzyl, p-nitrobenzyl, diphenylmethyl, tri(lower alkyl)silyl, lower alkoxymethyl, 2,2,2-trichloroethyl, ##STR3## Y is halogen or lower alkoxy; R 1 is lower alkyl, phenyl, or substituted phenyl; and X is hydrogen, lower alkanoyloxy, ##STR4## or certain heterothio groups; R 4 is hydrogen or lower alkyl; R 5 is lower alkyl; are disclosed. These compounds, particularly the free acids, possess the useful pharmacological property of inhibiting β-lactamase enzymes as well as being useful as intermediates, particularly where R is a readily cleavable ester, in the preparation of antibacterially active 6α-methoxy penicillins and 7α-methoxy cephalosporins. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4302581-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4291160-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20000073152-A |
priorityDate | 1976-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 286.