http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4169011-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4e5aca95e88bbf672b211a9427a5b8e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-20 |
| filingDate | 1977-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1979-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f206370f63b8ba33ba7fb84e974b51f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bf1c3b7b67d7f423b6c060166b804e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a6d06b204563d64018c50f5c2e45bf8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96ca08e6eff7a0dfb790d6c28639dc1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a534c11670d72917b5cef706e04dea23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35c28a2a0678454b6947fa970fe69d19 |
| publicationDate | 1979-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4169011-A |
| titleOfInvention | Facile synthesis of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) |
| abstract | 3'-Phosphoadenosine 5'-phosphosulfate, also known as PAPS, is useful in establishing sulfate transfer mechanisms in animals and may be produced by a chemical process yielding 68-72% product from a pure adenosine 2',3'-cyclic phosphate 5'-phosphate, which compound is initially prepared from the reaction of adenosine and pyrophosphoryl chloride. In the present procedure the pure cyclic phosphate is reacted with triethylamine-N-sulfonic acid to produce 2',3'-cyclic phosphate 5'-phosphosulfate. Subsequently, by hydrolysis with the enzyme ribonuclease-T2, the desired compound is produced. Alternatively, the 2'-phosphoadenosine 5'-phosphosulfate, known as iso-PAPS, may be produced from 2',3'-cyclic phosphate 5'-phosphosulfate by treatment with a different enzyme, PDase or spleen phosphodiesterase. This latter compound, iso-PAPS, biologically has only one-third the activity of PAPS, the natural isomer. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0485232-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4266048-A |
| priorityDate | 1977-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 132.