| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bdf849c32d7e0f41780c1a6b776dc1e3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-06 |
| filingDate |
1975-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1979-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e25401d0be48b82d9af12182f5ced0a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6abf8b0ed609fc53d6485d1fea5c1101
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcc06fa65c51b1729e68ec8ce051aedd |
| publicationDate |
1979-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4168375-A |
| titleOfInvention |
Process for the recovery of cephalosporin C and derivatives thereof |
| abstract |
A process for the recovery of cephalosporin C from an aqueous medium, including the steps of treating the medium with a sulphonyl chloride of formula R--SO 2 Cl, in which R is a substituted or unsubstituted alkyl group having from 4 to 10 carbon atoms, or a substituted or unsubstituted aryl group, to convert the cephalosporin C to the corresponding sulphonamide and extracting the sulphonamide with an essentially water immiscible solvent. The sulphonyl chloride may be toluene-p-sulphonyl chloride, p-isopropylbenzenesulphonyl chloride or β-naphthalenesulphonyl chloride. The molar ratio of sulphonyl chloride to cephalosporin C present in the aqueous medium is from 3 to 10. The temperature of the reaction of sulphonyl chloride with cephalosporin C is maintained in the range from 10° to 20° C. The water immiscible solvent is selected from ethyl acetate, n-butanol and methylisobutylketone. The pH of the reaction medium is maintained at a value of from 7.5 to 9.5 by means of a buffering agent. The extraction of the sulphonamide of cephalosporin C is carried out at a pH of from 1 to 4. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5801241-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9804564-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9804565-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4495348-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-1065865-C |
| priorityDate |
1974-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |