| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-36 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate |
1976-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1978-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33e91ebade7c7c8f39f8a7ec48088702
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_770752c2bb02d8ba76e3908dcef729f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_613eed73ccd287298af5520db8cc2146 |
| publicationDate |
1978-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4129731-A |
| titleOfInvention |
Process for converting 3-methylene cephalosporins to 3-heterothiomethyl cephalosporins |
| abstract |
This invention relates to the preparation of 3-heterothiomethyl cephalosporanic acid esters of the formula <IMAGE> by treating a 3-methylene cephalosporin of the formula <IMAGE> with a compound of the formula HETERO-S-S-hetero or X-S-hetero IN THE PRESENCE OF A BASE WHEREIN R is a readily removable ester group, R1 is in the alpha -configuration and is hydrogen or methoxy, and X is a leaving group. The resulting 3-heterothio cephalosporin esters are treated according to known methods to remove the ester protecting group and yield the corresponding free acids which have antibacterial activity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4311837-A |
| priorityDate |
1976-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |