| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a981026a679214e0ed7d4b0aa916e2a6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06104 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-072 |
| filingDate |
1976-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1978-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e38b7ff4a9ea69a87a3d30ea8e56a23 |
| publicationDate |
1978-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4113858-A |
| titleOfInvention |
Novel compounds, compositions and methods of their use |
| abstract |
Synthetic compounds of the formula: ##STR1## are disclosed wherein X is an integer of at least 0 and A and B each represent a divalent moiety of the formula: ##STR2## WHEREIN R 1 and R 5 are each selected from the residue of an amino acid or a polypeptide; R 2 represents the residue of tryptophan or tyrosine; R 3 represents the residue of an amino acid; R 4 represents the residue of lysine; arginine or histidine; a is an integer of 0 to 4, inclusive; b and c are each integers of at least 0; m is an integer of from 0 to 1, inclusive; and n is an integer of at least 1; provided that when R 1 or R 5 is the residue of a polypeptide, the corresponding b or c is 1. n The disclosure is also of intermediate compounds for preparing the compounds of the above formula and derivative compounds having biological activity. n Disclosed also are pharmaceutical compositions wherein the essential active ingredient is a synthetic compound of the invention and methods of using them for the prevention, suppression, treatment and diagnosis of multiple sclerosis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4294818-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4187295-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5645997-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003125306-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003083521-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5380710-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8420698-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006160902-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8034777-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7842727-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4223016-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6495719-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5883227-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7312247-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005209156-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7902259-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004167184-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008312324-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4230696-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8026280-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-4211878-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8138225-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7368429-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006062776-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7314953-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4331145-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4215111-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9486421-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7858664-B2 |
| priorityDate |
1975-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |