| abstract |
The present specification; provides bicyclic nitrogen-containing 9,11,15-trideoxy-prostaglandin F analogs which are useful anti-inflammatory agents, anti-asthma agents, and platelet aggregation inhibitors, and a process for their preparation. Included are compounds of the following structural formulas: <IMAGE> <IMAGE> <IMAGE> Especially described in the present specification are 9,11-trideoxy-9 alpha ,11 alpha -azo-PGF-type; 9,11,15-trideoxy-11 alpha ,9 alpha -epoxyimino-PGF-type; 9,11,15-trideoxy-9 alpha ,11 alpha -epoxyimino-PGF-type; N,N'-dialkyl-9,11,15-trideoxy-9 alpha 11 alpha -hydrazino-PGF-type; N,N'-bis(alkylcarbonyl)-9,11,15-trideoxy-9 alpha ,11 alpha -hydrazino-PGF-type; N-alkyl-9,11,15-trideoxy-11 alpha ,9 alpha -epoxyimino-PGF-type; N-(alkylcarbonyl)-9,11,15-trideoxy-11 alpha ,9 alpha -epoxyimino-PGF-type; N-alkyl-9,11,15-trideoxy-9 alpha ,11 alpha -epoxyimino-PGF-type; N-(alkylcarbonyl)-9,11,15-trideoxy-9 alpha ,11 alpha -epoxyimino-PGF-type; 9,11,15-trideoxy-9 alpha ,11 alpha -alkylhydrazino-PGF-type; 9,11,15-trideoxy-9 alpha ,11- alpha -(alkylcarbonyl)hydrazino-PGF-type; 9,11,15-trideoxy-11 alpha ,9 alpha -alkylhydrazino-PGF-type; and 9,11,15-trideoxy-11 alpha ,9 alpha -(alkylcarbonyl)-hydrazino-PGF-type compounds. |