| abstract |
Geminal prostaglandins (P.G.'s) are synthesized which are represented by the general formula: ##STR1## where A is a 4 or 5 carbon atom ring-completing group (CH 2 ) 1+m --X--(CH 2 ) z where m = 0, 1 or 2, n Z = 0 or 1, 0<(m + z)<3, and X is --CH 2 --CH 2 --, --CH 2 --CHOH--, ##STR2## and, when m = 0 and z = 1, is also --CH=CH-- or ##STR3## Y is divalent straight chain alkylene of 4 to 8 carbon atoms or n n --CH.sub.2 CH=CH(CH.sub.2).sub.3 --; n n r is alkyl of 4 to 7 carbon atoms; n Q is --CO 2 H or --CH 2 OH provided that it is not --CH 2 OH when X = ##STR4## or Y--Q taken together may be heptyl or allyl. |