| abstract |
Biphenylyl ethers of the formula R-O-CH2-CR1(OH)-CH2Z wherein R1 is H or CH3; Z is dialkylamino of 2-8 carbon atoms, morpholino, pyrrolidino, piperidino, homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino; R is either biphenylyl substituted by at least one of F, Cl, Br, I, CF3, NO2 and piperidino or, when R1 is CH3 or when Z is homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino, unsubstituted biphenyl, and the physiologically acceptable acid addition salts thereof, possess cholesterol blood-level-lowering activity and can be produced by reacting a compound of the formula R-O-CH2-Y wherein Y is <IMAGE> or -CR1(OH)-CH2X, X being Cl, Br, I or a free or functionally modified OH-group, with an amine of the formula H-Z. |