http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4056533-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-52 |
| filingDate | 1975-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1977-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d00dfda3aeed5cdd3a3a8dc4f044f92d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31c4f0134e1ef369b542c753ef73bbb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2cfedeb78d4ff96319c6dba9b26319f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_713b00f0c2e4f1509843b846f90cd55a |
| publicationDate | 1977-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4056533-A |
| titleOfInvention | Pyrazol-5-ones |
| abstract | 1-Substituted pyrazole-5-ones of the formula ##STR1## and pharmaceutically acceptable, nontoxic salts thereof, wherein R is hydrogen or amino; n R 1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralky; n X is n A. ethylene, ethylene wherein 1 hydrogen atom on one of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, ethylene wherein 1 hydrogen atom on each of the two carbon atoms is substituted by alkyl of 1 to 4 carbon atoms or said ethylene which is linked to R 2 via an oxygen or sulphur atom; n B. propenyl, propenyl wherein 1 hydrogen atom on one, two or three of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, said propenyl being linked to the N 1 atom of the pyrazol ring via its methylene moiety; or n C. methylene; n Provided that when X is methylene, R 1 is not hydrogen if R is amino; n R 2 is aryl unsubstituted or substituted by: n A. 1 or 2 of the same or different substituents selected from the group consisting of halogen, trifluoromethyl, alkyl of 1 to 8 carbon atoms, alkenyl of 2 to 8 carbon atoms and lower alkoxy; n B. cycloalkyl of 5, 6 or 7 carbon atoms or cycloalkenyl of 5, 6 or 7 carbon atoms; n C. alkylamino, dialkylamino, cyano, trifluoromethoxy, nitro, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, or said carbamoyl wherein the nitrogen atom is a member of a heterocyclic ring, sulphamyl, alkylsulphamyl, dialkylsulphamyl, or said sulphamyl wherein the nitrogen is a member of a heterocyclic ring, or --SO n alkyl wherein n is 0, 1 or 2; n D. alkylamino, dialkylamino, cyano, trifluoromethoxy, nitro, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, or said carbamoyl wherein the nitrogen atom is a member of a heterocyclic ring, sulphamyl, alkylsulphamyl, dialkylsulphamyl or said sulphamyl wherein the nitrogen is a member of a heterocyclic ring, or --SO n --alkyl wherein n is 0, 1 or 2, and 1 or 2 of the same or different substituents selected from the group consisting of alkyl, alkenyl, alkoxy, halogen, and trifluoromethyl; or n e. a fused, saturated or unsaturated 5-, 6-, or 7-membered ring or said ring containing 1 or 2 oxygen or sulphur atoms; n are useful for their diuretic, saluretic, antihypertensive and antithrombotic effects. n This is a division of Ser. No. 461,285 filed April 15, 1974 now U.S. Pat. No. 3,952,008. |
| priorityDate | 1973-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1405.