http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4055649-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bba842fc4d37dfcaced1b55bc0c91c7c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-08 |
| filingDate | 1976-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1977-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bbd2cc9defe5161f100e149789f1824 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71e3172f74a56da31965b39dfcc345c7 |
| publicationDate | 1977-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4055649-A |
| titleOfInvention | 4-Alkyl-2,6-di-(secondary or tertiary alkyl)amino-3-formylpyridines pharmaceutical compositions thereof and their use in the treatment of obesity and diabetes |
| abstract | Compounds of the formula <IMAGE> wherein R is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms, R' is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms, R1 is primary or secondary alkyl of 1 to 5 carbon atoms, and R2 is hydrogen, chloro or bromo, AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, ARE USEFUL AS ANTI-OBESITY AND ANTI-DIABETIC AGENTS. The compounds wherein R and R' are tertiary alkyl of 4 to 7 carbon atoms and R2 is hydrogen are synthesized from ketenimines and amidines, all of the compounds wherein R2 is hydrogen are synthesized by reduction of the corresponding 3-cyanopyridines, and the compounds wherein R2 is chloro or bromo are synthesized from the corresponding compounds wherein R2 is hydrogen and an N-halosuccinimide. |
| priorityDate | 1976-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 213.