http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4054741-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12cedce8d26d81271038993ba4912fe6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C57-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-42 |
| filingDate | 1976-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1977-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6226131304b1d21eb5df04d6a54d031c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0acfb0a5e8e002734723515542d0c5ca |
| publicationDate | 1977-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4054741-A |
| titleOfInvention | Derivatives of prostanoic acid |
| abstract | Process for preparing prostanoic acid derivatives, in particular derivatives of 9,15-dioxygenated prostanoic acid and prost-13-enoic acid, related additionally unsaturated derivatives, homologs thereof and intermediates therefor, in which a lower alkyl ester of 2-(ω-carboxy-Y)cyclopent-2-en-1-one in which Y is CH 2 --(a)--(CH 2 ) m wherein (a) is CH 2 CH 2 , CH═CH or C.tbd.C and m is an integer from 2 - 4 is treated with nitromethane to yield 2-(ω-carboxy-Y)-3-nitromethyl-cyclopentan-1-one and the latter compound or its corresponding 1-hydroxy analog are converted to the corresponding aldehyde, 2-(ω-carboxy-Y)cyclopentan-1-on-3-al or 1-hydroxy-2-(ω-carboxy-Y)cyclopentan-3-al, respectively. Treatment of the aldehyde with the ylid prepared from the appropriate Wittig reagent, preferably a dimethyl 2-oxoalkylphosphonate of the formula (AlkO) 2 P(O)CH 2 CO(CH 2 ) n CH 3 in which n is an integer of from 1-6 and Alk is an alkyl containing from 1 - 3 carbon atoms yields the corresponding derivatives of 2-(ω-carboxy-Y)-3-(3-oxoalk-1-enyl)cyclopentan-1-one or -1-o1 in which the oxygen functions may be selectively protected and transformed by conventional means, and in which the unsaturated bonds may be reduced to a single bond. The prostanoic acid derivatives possess prostaglandin like biological activities. Methods for their use are also disclosed. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5152003-A |
| priorityDate | 1975-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1617.