http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4049664-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_39ae96c0ecc22ff90ff986371a3cea0f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 |
| filingDate | 1976-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1977-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4f6e69a3a4d6e5f46ed386716a20791 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_998a9969d9ad40a5b2d6d353f2e1f5c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_073a53e51d568fb0352cfe2da5381b76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_061014db940f1919ab8fe39c161682cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a585cd6259ac332635b157bc1352a0a1 |
| publicationDate | 1977-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4049664-A |
| titleOfInvention | Chromone compounds |
| abstract | Chromone compounds having the structure (I) <IMAGE> (I') <IMAGE> wherein R is aryl, substituted aryl, thienyl, furyl or pyridyl, Y is hydroxy (lower) alkylene, R1 is hydrogen, lower alkyl, aryl, substituted aryl or a heterocyclic group, R2 is hydrogen or lower alkoxy, Y1 is lower alkylene or hydroxyl (lower) alkylene, Z is oxygen or sulfur and R3 is hydrogen, lower alkyl, aryl, substituted aryl, or ar(lower)alkyl have anti-allergic activity and are useful in the treatment of asthma. Compounds of the structure [I] are prepared by reacting (II) <IMAGE> wherein Y' is hydroxy (lower) alkylene whose hydroxy group is optimally protected or a reactive derivative of [II] with a carboxylic acid of the formula R-COOH in the presence of a basic catalyst. The resulting compound is then reacted with an acid. Compounds of the structure [I] are prepared by reacting the compound (IV) <IMAGE> with the compound X-Y1'-Z-R3' wherein X is an acid residue, Y' is lower alkylene or hydroxy (lower) alkylene whose hydroxy group is optionally protected by a protective group, R3' is hydrogen, lower alkyl, aryl, substituted aryl, or ar(lower)alkyl and Z is defined above. When R3' is hydrogen, -Z-R3' is optionally protected by a protective group. The resultant compound is subjected to an elimination reaction when Y' is a protected group or when -Z-R3' is protected to split off the protective group. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4105781-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5263340-A |
| priorityDate | 1970-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 309.