| abstract |
Lyophilizable, clottable fibrinogen free, Factor VIII is produced on a commercial scale from a fibrinogen containing Factor VIII concentrate by sequentially, precipitating a major portion of the clottable fibrinogen by the addition of an ethylene oxide-polyoxypropylene block copolymer, clotting the remainder of the clottable fibrinogen by the addition of a small amount of a thrombin mimetic enzyme which does not decrease the potency of the Factor VIII, and adding human albumin to the resultant clottable fibrinogen free Factor VIII to stabilize its potency during lyophilization. |