| abstract |
Novel pharmaceutical methods, combinations and compositions for reducing gastric bleeding during aspirin therapy for inflammation are disclosed. Compounds used in combination with aspirin are phenylalkylamines and phenylalkylureas having the formula: <IMAGE> wherein Z is selected from the group consisting of -NHR2 or <IMAGE> and R is selected from the group consisting of hydrogen, halogen, lower-alkoxy and trifluoromethyl and R1, R2, R3 and R4 are selected from the group consisting of hydrogen and lower-alkyl, where R3 and R4 taken together with the adjacent nitrogen atom may form a heterocyclic ring selected from the group of piperidino, pyrrolidino, piperazino, and morpholino. |