| abstract |
Thiazole derivatives represented by the general formula: <IMAGE> wherein A is oxygen, sulfur, imino, or NR3, wherein R3 is C1-5 alkyl, C2-5 alkenyl, C3-5 alkynyl, C3-6 cycloalkyl-C1-3 alkyl or C7-8 aralkyl; R1 is hydrogen, C1-5 alkyl, C2-5 alkenyl, C3-5 alkynyl, C3-6 cycloalkyl-C1-3 alkyl or C7- 8 aralkyl; R2 is hydroxy, C1-5 alkoxy or OM, wherein M is alkali metal, or one equivalent of alkaline earth metal, cupric or aluminum cation; n is an integer of 0 or 1; X1 and X2 are independently hydrogen or C1-5 alkyl; Y1 and Y2 are independently hydrogen, halogen, C1-5 alkyl, C1-5 alkoxy or trifluoromethyl; and the group <IMAGE> is linked to one of the meta or para positions of the benzene ring A, n is not 0 when A is imino and -CH2-COR2 does not substitute the thiazole ring when A is imino, being useful as anti-inflammatory, anti-rheumatic, analgesic or anti-lipemia agents. |