| abstract |
CNS depressants of the formulae IA and IB: ##STR1## in which n and p are each 0 or 1, Z - is an anion and R 1 , R' 1 , R 2 , R' 2 , R 3 and R 4 are optional substituents. Compounds IB may be prepared by reducing compounds IA which may be made by reacting a N-(ω-haloalkyl) isatoic anhydride with a cyclic pseudothiourea such as a 2-organomercapto-4,5-dihydroimidazole. Compounds IB may be also prepared by cyclizing a 1-(ω-haloalkyl)-2,3-dihydro-imidazo[2,1-b]quinazolin-1H-5-one. The compounds are anti-inflammatory, analgesic and immunosuppressant agents. |