http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4003904-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-06 |
| filingDate | 1975-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1977-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_737f0a183c991fa0ec9c951171184c48 |
| publicationDate | 1977-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4003904-A |
| titleOfInvention | Anti-diarrheal oxadiazoles |
| abstract | The present invention encompasses a compound of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein Y is alkylene having 1-4 carbon atoms; R 1 and R.sub. 2 together with N is a heterocyclic ring system consisting of an azamonocyclic ring of the formula ##STR2## wherein Z is oxygen, methylene, phenylhydroxymethylene, phenylcarboxymethylene or, phenylloweralkoxymethylene, or an azabicycloalkane structure having 6-9 carbon atoms and having at least 5 atoms in each ring of the azabicycloalkane structure; X is hydrogen, halogen, loweralkyl having 1-7 carbon atoms, or loweralkoxy having 1-7 carbon atoms; and Ar is phenyl, pyridyl, or monosubstituted phenyl wherein the substituent is halogen, loweralkyl having 1-7 carbon atoms, or loweralkoxy having 1-7 carbon atoms when R 3 is hydrogen or Ar is 3 or 4 pyridyl when R 3 is lower alkyl having 1-7 carbon atoms. n The compounds of the present invention are prepared by converting the corresponding nitriles to 1H-tetrazoles and in turn reacting the 1H-tetrazole with ethyl chloroglyoxylate, hydrolyzing the resulting ester to the acid and decarboxylation to provide compounds wherein R 3 is hydrogen. Compounds of the present invention are anti diarrheal agents. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5290795-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4194045-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4182884-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4053477-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5187164-A |
| priorityDate | 1974-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 337.